Why are nanofibers used in biosensors and diagnostic devices?
Nanofibers have found extensive applications in biosensors and diagnostic devices, revolutionizing the field of medical diagnostics and healthcare monitoring. Their unique properties enable enhanced sensitivity, selectivity, and performance in detecting and measuring biological analytes.
High Surface Area-to-Volume Ratio
Nanofibers have a large surface area, allowing for enhanced interaction with target molecules. This property increases the chances of analyte binding, resulting in improved sensitivity and detection limits.
Biorecognition and Affinity
Nanofibers can be functionalized with biorecognition elements such as antibodies, enzymes, or DNA probes. These functionalized nanofibers enable specific binding to target analytes, enhancing the selectivity and accuracy of biosensors and diagnostic devices.
Nanofibers can be engineered to amplify signals generated by target-analyte interactions. For example, nanofibers can act as carriers for nanoparticles or reporter molecules, resulting in signal enhancement and improved detection sensitivity.
Fast Response Time
The high porosity and small dimensions of nanofibers enable rapid analyte diffusion and interaction. This property allows for faster response times, making nanofiber-based biosensors suitable for real-time or point-of-care diagnostic applications.
Stability and Longevity
Nanofibers can offer stability and longevity to biosensors and diagnostic devices. They can withstand harsh environments, maintain their structural integrity, and retain their functional properties over time, ensuring the reliability and durability of the devices.
Flexibility and Conformability
Nanofibers can be fabricated into flexible and conformable structures, enabling their integration into wearable or implantable biosensors. This property allows for non-invasive and continuous monitoring of analytes, enhancing the practicality and usability of the devices.
Integration with Microfluidics
Nanofibers can be seamlessly integrated with microfluidic systems, facilitating sample handling and analyte transport. This integration enables efficient analyte capture, separation, and analysis, enhancing the overall performance of biosensors and diagnostic devices.
Nanofiber-based biosensors can be designed to detect multiple analytes simultaneously, allowing for multiplexed analysis. This property enables the detection of multiple biomarkers or analytes in a single test, improving the efficiency and cost-effectiveness of diagnostics.